• Natálie Klubíčková, Bc, MD, PhD, MSc
    Natálie Klubíčková, Bc, MD, PhD, MSc

    consultant

List of publications

  1. Klubíčková N, Agaimy A, Hájková V, Ptáková N, Grossmann P, Šteiner P, et al. RNA-sequencing of myxoinflammatory fibroblastic sarcomas reveals a novel SND1::BRAF fusion and 3 different molecular aberrations with the potential to upregulate the TEAD1 gene including SEC23IP::VGLL3 and TEAD1::MRTFB gene fusions. Virchows Arch. 2022;481(4):613-20.
  2. Klubíčková N, Billings S, Dermawan JKT, Molligan JF, Fritchie K. Ossifying fibromyxoid tumours with lipomatous and cartilaginous differentiation: A diagnostic pitfall. Histopathology. 2025;86(6):891-9.
  3. Klubíčková N, Dermawan JK, Mosaieby E, Martínek P, Vaněček T, Hájková V, et al. Comprehensive clinicopathological, molecular, and methylation analysis of mesenchymal tumors with NTRK and other kinase gene aberrations. J Pathol. 2024;263(1):61-73.
  4. Klubíčková N, Gross JM, Comová K, Kuruc J, Michal M. A novel FUS::NFATC4 fusion detected in a sarcoma with morphological features overlapping with NFATC2 sarcomas. Histopathology. 2024;84(2):413-5.
  5. Klubíčková N, Grossmann P, Šteiner P, Baněčková M, Mosaieby E, Koshyk O, et al. A minority of cases of acinic cell carcinoma of the salivary glands are driven by an NR4A2 rearrangement: the diagnostic utility of the assessment of NR4A2 and NR4A3 alterations in salivary gland tumors. Virchows Arch. 2023;482(2):339-45.
  6. Klubíčková N, Kinkor Z, Michal M, Baněčková M, Hájková V, Michálek J, et al. Epithelioid Soft Tissue Neoplasm of the Soft Palate with a PTCH1-GLI1 Fusion: A Case Report and Review of the Literature. Head Neck Pathol. 2022;16(2):621-30.
  7. Klubíčková N, Loghides F, van den Hout M, Costes-Martineau V, Ferrara G, Rito M, et al. Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands. Am J Surg Pathol. 2025.
  8. Klubíčková N, Michal M, Agaimy A, Zidar N, Pavlovský M, Yorita K, et al. TIMP3::ALK fusions characterize a distinctive myxoid fibroblastic tumor of the vocal cords: a report of 7 cases. Virchows Arch. 2022;481(5):721-9.
  9. Klubíčková N, Michal M, Kinkor Z, Soukup J, Ryška A, Brtková J, et al. Poorly differentiated extra-axial extraskeletal chordoma diagnosed by methylation profiling: case report and analysis of brachyury expression in SWI/SNF-deficient tumors. Virchows Arch. 2024;484(4):621-7.
  10. Klubíčková N, Mosaieby E, Ptáková N, Trinquet A, Laé M, Costes-Martineau V, et al. High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology. Virchows Arch. 2023;483(2):187-95.
  11. Koshyk O, Dehner CA, van den Hout M, Bempt IV, Sciot R, Huang HY, et al. EWSR1::POU2AF3(COLCA2) Sarcoma: An Aggressive, Polyphenotypic Sarcoma With a Head and Neck Predilection. Mod Pathol. 2023;36(12):100337.
  12. João D, Feltri M, Klubickova N, Michal M, Kacerovská D, Skálová A. Apocrine variant of intraductal carcinoma of the parotid gland with sebaceous-like differentiation: expanding morphological and molecular spectrum of an enigmatic entity. Virchows Arch. 2024.
  13. Lasota J, Chłopek M, Kaczorowski M, Natálie K, Ryś J, Kopczyński J, et al. Utility of Immunohistochemistry With Antibodies to SS18-SSX Chimeric Proteins and C-Terminus of SSX Protein for Synovial Sarcoma Differential Diagnosis. Am J Surg Pathol. 2024;48(1):97-105.
  14. Lenz J, Klubíčková N, Ptáková N, Hájková V, Grossmann P, Šteiner P, et al. Extraskeletal myxoid chondrosarcoma: A study of 17 cases focusing on the diagnostic utility of INSM1 expression and presenting rare morphological variants associated with non-EWSR1::NR4A3 fusions. Hum Pathol. 2023;134:19-29.
  15. Macedo RT, Baranovska-Andrigo V, Pancsa T, Klubíčková N, Rubin BP, Kilpatrick SE, et al. Nuclear DUX4 immunohistochemistry is a highly sensitive and specific marker for the presence of CIC::DUX4 fusion in CIC-rearranged sarcomas: a study of 48 molecularly confirmed cases. Histopathology. 2025;86(3):423-32.
  16. Meyer A, Klubíčková N, Mosaieby E, Grossmann P, Kalmykova A, Koshyk O, et al. Biphenotypic sinonasal sarcoma with PAX3::MAML3 fusion transforming into high-grade rhabdomyosarcoma: report of an emerging rare phenomenon. Virchows Arch. 2023;482(4):777-82.
  17. Michal M, Agaimy A, Croce S, Mechtersheimer G, Gross JM, Xing D, et al. PLAG1-Rearranged Uterine Sarcomas: A Study of 11 Cases Showing a Wide Phenotypical Spectrum Not Limited to Myxoid Leiomyosarcoma-Like Morphology. Mod Pathol. 2024;37(9):100552.
  18. Michal M, Kuruc J, Hájková V, Michalová K, Klubíčková N. S100 and CD34 positive spindle cell tumors of the uterine cervix with EGFR mutation: a hitherto unrecognized neoplasm phenotypically and epigenetically overlapping with "NTRK-rearranged spindle cell neoplasms" of the uterus. Virchows Arch. 2024.
  19. Michal M, Ud Din N, Švajdler M, Klubíčková N, Ptáková N, Hájková V, et al. TFG::MET-rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low-grade triphasic morphology. Genes Chromosomes Cancer. 2023;62(5):290-6.
  20. Pancsa T, Klubíčková N, Dashti NK, Machado I, Llombart-Bosch A, Linos K, et al. GLI1::FOXO4-rearranged kidney tumors: a potentially distinct renal subtype within the spectrum of GLI1-altered tumors? Virchows Arch. 2025;486(4):751-7.
  21. Skálová A, Baněčková M, Laco J, Di Palma S, Agaimy A, Ptáková N, et al. Sclerosing Polycystic Adenoma of Salivary Glands: A Novel Neoplasm Characterized by PI3K-AKT Pathway Alterations-New Insights Into a Challenging Entity. Am J Surg Pathol. 2022;46(2):268-80.
  22. Skálová A, Bradová M, Michal M, Jr., Mosaieby E, Klubíčková N, Vaněček T, et al. Molecular pathology in diagnosis and prognostication of head and neck tumors. Virchows Arch. 2024;484(2):215-31.
  23. Skálová A, Klubíčková N, Bradová M, Agaimy A, Rupp NJ, Damjanov I, et al. Discovery of Novel TULP4/ACTN4/EWSR1/ACTB::MYB and ESRRG::DNM3 Fusions Expands Molecular Landscape of Adenoid Cystic Carcinoma Beyond Fusions Between MYB/MYBL1 and NFIB Genes. Am J Surg Pathol. 2024;48(12):1503-11.
  24. Skálová A, Taheri T, Bradová M, Vaněček T, Franchi A, Slouka D, et al. SMARCB1-deficient sinonasal adenocarcinoma: a rare variant of SWI/SNF-deficient malignancy often misclassified as high-grade non-intestinal-type sinonasal adenocarcinoma or myoepithelial carcinoma. Virchows Arch. 2024;485(2):245-56.

Lectures

  1. Sklíčkový seminář patologických pracovišť, 30.9.-1.10.2021, Lednice:
    Lecture: Tumor hlasivky s TIMP3::ALK fúzí.
  2. 34th European Congress of Pathology, 3-7.9.2022, Basilej:
    Lecture 1: A single-institution experience with 128 cases of acinic cell carcinoma: diagnostic utility of NR4A3 and NR4A2 immunohistochemistry in salivary glands pathology,
    Lecture 2: A single institution experience with 17 cases of extraskeletal myxoid chondrosarcoma: rare fusion, unusual morphology and the utility of INSM1 immunohistochemistry.
  3. 47. Sjezd českých patologů, 3.-5.11.2022, Praha:
    Lecture: Tumory s diferenciací do příčně pruhované svaloviny: přehled novinek a diferenciální diagnostika.
  4. Sklíčkový seminář patologických pracovišť, 10.-11.11.2022, Mikulov:
    Lecture 1: Novinky v mezenchymálních lézích s diferenciací do příčně pruhované svaloviny,
    Lecture 2: Hyalinizující světlobuněčný karcinom slinné žlázy rtu s fúzí SMARCA2::CREM, Přednáška 3: Sinonasální solitární fibrózní tumor.
    Lecture 3: Sinonasální solitární fibrózní tumor.
  5. Večer Šiklova ústavu patologie, 26.4.2023, Plzeň:
    Lecture: Kaposiho sarkom jako komplikace dlouhodobé kortikoterapie.
  6. Studentská vědecká konference Lékařské fakulty v Plzni, 17.5.2023, Plzeň:
    Lecture: Targeted RNA sequencing of ossifying fibromyxoid tumor reveals novel PHF1::AFF3, PHF1::KLF15, BMI1::EPC1, and SUZ12::EPC1 gene fusions and unusual morphological features.
  7. Sklíčkový seminář patologických pracovišť, 9.-10.11.2023, Mikulov:
    Lecture 1: Mesenchymální vřetenobuněčné tumory s alteracemi genů pro proteinkinázy: Přehled a nové poznatky,
    Lecture 2: Metatypický adenoidně cystický karcinom parotis,
    Lecture 3: Palisádující adenokarcinom submandibulární žlázy.
  8. Večer Šiklova ústavu patologie, 17.4.2024, Plzeň:
    Lecture: Co se také může skrývat za klinicky suspektním karcinomem?
  9. 36th European Congress of Pathology, 7-11.9.2024, Florencie:
    Lecture: A basket of surprising cases: Pseudoendocrine sarcoma.
  10. 49. Sjezd českých patologů, 2.-4.10.2024, Ostrava:
    Lecture: Novinky ve WHO klasifikaci nádorů hlavy a krku: Mesenchymální léze.
  11. Sklíčkový seminář patologických pracovišť, 6.-8.11.2024, Mikulov:
    Lecture: Pseudoendokrinní sarkom.
  12. 114th USCAP, 22.-27.3.2025, Boston:
    Lecture: Ossifying fibromyxoid tumor: From morphology to methylation profiling.
  13. 13th International Arkadi M. Rywlin Pathology Slide Seminar, 16.-18.6.2025, Plzeň, prezentováno doc. Michalem:
    Lecture 1: EGFR mutated polypoid spindle cell tumor of the cervix,
    Lecture 2: Ossifying fibromyxoid tumor with EP300::BCORL1 fusion.
  14. 50. Sjezd českých patologů, 25.-26.9.2025, Plzeň:
    Lecture: Diagnostická patologie nádorů slinných žláz: Imunohistochemické a molekulárně-genetické testování.

Posters

  1. 111th USCAP, 19.-24.3.2022, Los Angeles, CA, USA:
    Poster 1: Targeted DNA and RNA sequencing of soft tissue spindle cell tumors reveals a rare MET::TFG and a novel PWWP2A::RET gene fusions as well as additional recurrent PIK3CA point mutations,
    Poster 2: Solitary fibrous tumor with pure round cell morphology: immunohistochemical and molecular study of 15 cases.
  2. 112th USCAP, 11.-16.3.2023, New Orleans, LA, USA:
    Poster 1: Targeted RNA sequencing of ossifying fibromyxoid tumors reveals novel PHF1 gene fusions and unusual morphologic features,
    Poster 2: SMARCB1-deficient sinonasal adenocarcinoma: Rare variant of SWI/SNF-deficient malignancy often misclassified as high-grade non-intestinal adenocarcinoma or myoepithelial carcinoma
  3. 113th USCAP, 23.-28.3.2024, Baltimore, MD, USA
    Poster 1: Ossifying fibromyxoid tumors with lipomatous and chondroid differentiation: A diagnostic pitfall,
    Poster 2: HMGA2 gene alterations define a distinctive canalicular subtype of salivary pleomorphic adenoma.

Prizes

  1. Lamblova cena za rok 2022.
  2. Lamblova cena za rok 2024.
  3. Cena Josefa Hlávky, 2024.
  4. Jeremy Jass Prize for Research Excellence in Pathology, 2024.